This Week in Startups Sponsors
This Week in Startups has produced 1,405 episodes. 293 of those episodes have been sponsored by 90 companies. We last recorded an episode on Apr 11, 2026.
Latest Episodes
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Bittensor Drama! TAO down 15%! | E2274
Apr 11, 2026This Week In Startups is made possible by:Pilot - https://pilot.com/TWISTSquarespace -https://squarespace.com/TWISTNorthwest Registered Agent - https://northwestregisteredagent.com/TWISTPlaud - https://Plaud.ai/twistCrowdHealth - https://JoinCrowdHealth.com/twistToday’s show:TAO, the token associated with the Bittensor network, fell sharply last night after a major project declared it was taking its business elsewhere. Covenant AI had used Bittensor subnets 3, 39, and 89 before its abrupt...
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Anthropic’s Mythos is a cyber-weapon, so you can’t have it | E2273
Apr 9, 2026Anthropic just built a model so dangerous, they’re not even going to release it (for now). On TWiST, Jason, Alex, and Neurometric CEO Rob May discuss whether or not this is just another frontier model or a potential weapon of mass internet destruction.Claude Mythos Preview is already in the hands of over 40 Anthropic partners — including Nvidia, Apple, Amazon, Microsoft, and Google — as part of its “Project Glasswing” security council.Together, they’ll test how quickly and easily the model...
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3 AI Agents That Actually Replaced Human Jobs | E2272
Apr 7, 2026Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top TWiST OpenClaw experts to break down what it means, how much it’s going to cost now, and whether this is truly the end of the subsidized AI era.And they all brought demos! We’re checking out ClawChief from Ryan Carson, Alex Finn’s agent Henry, and Yazin Alirhayim’s Sidecast protocol, inspired by a special request from JCal!HostsJason Calacanis:...
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AI Rebuilt Every YC W26 Startup. Should Founders Be Scared? | E2271
Apr 3, 2026This Week In Startups is made possible by:Deel - deel.com/twistGrasshopper Bank - grasshopper.bank/twistRender - render.com/twistPlaud - Plaud.ai/twistAn AI “holding company” rebuilt dozens of YC Winter ‘26 startups in one weekend. Now we’re bringing the founder responsible into Jason’s Courtroom to defend himself.PLUS a live demo of Boardy, the AI that acts like a virtual board member and makes crucial introductions. Find out why he gets to have so much agency, how creator Andrew D’Souza...
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How 3 CEOs Use AI to Run $10B in Companies | This Week in AI
Apr 2, 2026This Week in AI, JCal sits down with three CEOs building the infrastructure, intelligence, and interfaces for the next era of AI: Jeremy Fraenkel (CEO, Fundamental), Victor Riparbelli (CEO, Synthesia), and Nick Harris (CEO, Lightmatter). We break down what's actually happening beneath the AI hype: the data modality LLMs completely missed, why copper is the real bottleneck in AI data centers, OpenAI shutting down Sora, the build vs. buy debate for AI tools, and how close we really are to...
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Venture Roundtable: SpaceX IPO, AI's PR Crisis, and the Defense Tech Bubble | E2270
Apr 1, 2026This Week In Startups is made possible by:PaperOS - https://PaperOS.com/twistNorthwest Registered Agent- https://northwestregisteredagent.com/twistEvery.io - https://Every.ioPlaud - https://Plaud.ai/twistToday’s show:Silicon Valley just lined up its biggest liquidity event in years: SpaceX filed confidentially for an IPO that could target a $1.75 trillion valuation — potentially the largest public offering in history. Meanwhile, a new Quinnipiac poll shows that 62% of Americans aren't excited...
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The 5-Step Framework for AI Agents That Improve While You Sleep | E2269
Mar 31, 2026This Week In Startups is made possible by:Quo - https://quo.com/TWiSTLinkedIn Jobs - https://LinkedIn.com/twistIru - https://iru.com/twistPlaud - https://Plaud.ai/twistToday’s show:Google project manager Shubham Saboo is running 6 AI agents on a Mac Mini that handle all of his side business autonomously, from research, to social posts, to newsletters.He joins Jason and Lon to walk us through his 5-step framework for designing an efficient AI agent team:Start with one agent and onboard them...
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The $60 billion resource hiding in space, and the start trying to mine it (feat. Matt Gialich, Astroforge) | E2268
Mar 27, 2026This Week In Startups is made possible by:Wispr Flow - https://wisprflow.ai/twistCircle - http://circle.so/twistDeel - http://deel.com/twistToday’s show:AstroForge is building low-cost, replicable spacecraft to mine platinum group metals from near-Earth asteroids — a $60 billion annual market for materials that are running out on Earth. Founder and CEO Matt Gialich joins the show to talk about the company's ambitious mission, what went wrong on their first two flights, and why Mission 3 could...
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This Bittensor Subnet Could Cut Drug Discovery Costs in HALF | E2267
Mar 26, 2026This Week In Startups is made possible by:Luma AI - https://lumalabs.ai/twistEvery.io - https://every.ioLemon.io - https://Lemon.io/twistPlaud - https://Plaud.ai/twistToday’s show:What do drug discovery, the creator economy, and AI vision models have in common? In the case of Metanova, Bitcast, and Score, the answer is Bittensor. Yes, each of the three companies leverages the Bittensor network to get more work done, more quickly, in a completely decentralized fashion.Metanova uses its subnet...
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$2.5B Chip Heist, The Future of American AI, and Purpose-Built Robots | This Week in AI Ep 6
Mar 25, 2026This Week in AI sneak peak! If you enjoy the episode find us on Spotify, Apple podcasts and YouTube by looking up "This Week in AI" or by going to thisweekinai.aiThis week Jason sat down with Jake Loosararian and Chris Lattner on Episode 6 of This Week in AI. Jake is the CEO and co-founder of Gecko Robotics, a company deploying purpose-built robots and AI for mission-critical infrastructure inspection across energy, defense, and manufacturing. Chris is the CEO and co-founder of Modular,...
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